:2 Twent -Third Annual
1997 PROGRAM y .
_______%___.____- Symposmm on
8:00 a.m. Registration and Coffee - Room 137, 10:40 a.m. Discussion
Chemistry-Physics Building
10:50 a.m. Dr. Kim D. Janda, The Scripps Re- '
8:45 a.m. Welcome by Dr. Fitzgerald Bramwell, search Institute and The Skaggs Chem IS'I'IY
Vice President for Research and Institute for Chemical Biology
Graduate Studies, University of Mom Combinatorics to Soluble Polymer &
Kentucky - Room 139, Chemistry- Supported Synthesis
Physics Building MOleCU IC"
' Encoded Combinatorial Chemis '
8:50 a.m. Introductory Remarks - Dr. Art . Recursive Deconvolution try BIOlogy
Cammers-Goodwin. Universrty 0f  Liquid Phase Combinatorial Synthesis of Peptides
Kentucky  Peptidomimetics, and Small Molecules
. _  Multipolymeric Reactions
9:00 a.m. Dr. Arno F. Spatola, Unwersrty of , C o mbi Zy m e s
Lomsvme  . ' Combinatorial Polymer Synthesis
Combinatorial Chemistry: The End of
Rational Drug Design? Lessons from _
Macrocyclic Libraries 11:40 a.m. Discussron
i 11:50 a.m. Dr. Hendrik Mario Geysen, Glaxo
. Basic combinatorial Methods Wellcome Pharmaceuticals Inc. . - '
. A Brief HitriFal Overview Combinatorial Chemistry: A New
'  A "Realistic" Vlew of the MethodsNot a Panacea Paradigmfor Drug Discovery . a ,
' Why So Much Industrial Attention? _ .
 Parallel Synthesis vs. Mixtures _ _ . ' . . ' eStabI'Shed In the memory 0f
. The Deconvolution Problem ' Personalized Historical View of Combinatorial . Anna 3_ Naff i
 ' Combinatorial Chemistry at the University of Lou- Chemlstry ' ' 
isville ' Combinatorial Chemistry: Perspective of the Phar v __________
maceutical Industry . .
_ .  Combinatorial Chemistry at Glaxo Wellcome The ROIG combmatonal
940 a.m. Discusswn  Combinatorial Approaches to Reaction Screening Chemistry in Drug DeSIgn
_ _  Encoding Strategies for Chemical Libraries
9:50 a.m. Dr. :Jonathan A. Ellman, Universrty of . Coupling Chemical Libraries with High Through _'
California at Berkeley put Screening of Biological Targets 3
Design, Synthesis, and Evaluation of >. O SPEAKERS
Small Molecule Libraries :3 C.)
12:40 p.m. Discussion .0 3 8 Jonathan A Ellman
e g to Hendrik Marlo Geysen
' General Philosophy for the Design of Combinato 1:00 p.m. Buffet Lunch Facult Club Please 21) E S Kim D. Janda
. ' y D 0
Hal Schemes . return registration form by April 1, LH M >.. Arno F- SpatOIa
' Prudent Selection of Classes of Compounds for 1997 for reservations. Cost $10.00 o 5 M
. . 43
Combinatorial Approaches to be paid at registration.) 5 >., ,5
' Heuristic Bioactivity of Known Drugs as Starting 5 a 9 Tuesday, April 8 1997
Pomts 1n Combinatorial Approaches 3100 P-m- Discussion with Graduate Students E; 5 at)
' Synthetic Approaches to Maximize Molecular Di Room 137 Chemistry-Physics 3 E '5
verSIty Building Q :3 A Department of Chemistry
University of Kentucky
E Lexington, Kentucky 40506-0055