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2011 PROGRAM C Thlrty-Seventh Annual
8:00 am. Registration & Continental Breakfast generally difcult to realize attributes. These include: the ability to .2 i. Symposium on
Keeneland Room, W.T. Young Library accommodate living systemcells or microorganlsmsas well as S o g ,_
8:50 am. Welcome by Dr. James Tracy highly functional/chemically complex materials; to sustain or manipu- E g E 1?
Vice President for late uid ows; enable dynamic molecular patterning that is elicited 97;; 9 Q 2 .
Research at University of Kentucky both temporally and spatially; embed complex multiscale, non-planar] O [E < ,5 t C h e m lstry
9:00 am. Dr. Georges Belfort curvalinear and 3D structural forms; and provide capacities for ena- 33 0)- r1 % E
Rensselaer Polytechnic Institute bling useful forms of mechanicsexure, folding, and actuation as 0': 3' .E 6'3 &
Proteins and Interfaces: Stability and Function examples. New materials and enabling means of fabrication are  3
_ _ . beginning to provide approaches to construct devices with properties 2 - .
Proteins are exposed to a multitude 0t dlfferent surfaces and of this type along with capacities for high performance. In this lecture M Olecu la r
chemistries in ViVo and yet, they must retain their stability in order I will describe a number of examples related to recently developed 3D
to function. However, conversion 0t soluble native proteins into 3 materials platforms and microuidic devices possessing utility to drive -
sheet-rich structured aggregates, such as amyloid and prion de- discovery in biological and bioanalytical chemistry. Of particular inter- BIOIOQy
posits can occur at interfaces. Protein stability and activity is also est will be examples taken from our recent work involving integrated
essential for use in various medical and analytical devices, such as 39 uidic platforms for sustaining and manipulating complex 31)
biosensors, biocatalytic chips, biocompatible materials for im- cellular microcultures of neurons and novel integrated tools for chemi-
plants, drug delivery vehicles, tissue engineering and beads or cal analysis that can be used to characterize both them and biologi-
membranes for bioseparations. Although a vast experimental lit cally relevant samples more generally. I will provide an overview of
erature exists on the adsorption of Specic proteins to various soiid the rapidly developing elds of soft and direct write fabrication meth-
substrates under dened conditions, difculties in determining the ods that can be used to construct these devices and suggest opportu-
underlying reasons for the loss of stability and function remain. nities as well as needs for future progress.
Many researchers have addressed particular aspects of protein
behavior at interfaces through experiment, theory and molecular 11:10 am. Poster Session, Gallery, Young Library ,
simulation. Here, we review recent results on protein stability and 12:30 pm. Lunch
activity on solid heterogeneous and homogeneous substrates, 2:00 pm. Dr. Paul S. Weiss 
demonstrate the effect of surface chemistry and roughness on University of California, Los Angeles 
protein aggregation, describe a novel method to probe unfolding of New Dimensions in Patterning: Placement and -
a monolayer of tethered proteins and introduce new NMR titration Metro/ogy of Chemical Functionality at All Scales establlShed by M' Benton Na
results with chromatographic data in order to study the nature of . _ in memory 0f Anna 8- Naif
protein adsorption in multimodal chromatography. We also mention Chemists have a desrre to construct materials atom-byatom and
the use of single molecule force spectroscopy to determine mo- molecule-by-molecule, and through the development 0t modern DOlY'
lecular interactions in the nuclear pore complex (NPC). Tethered mer chemistry, coordination chemistry, and crystal engineering. They ,_'_"
bril-like proteins that contain intrinsically disordered domains have become moderately procient at realizing target structures. BIOChGMIStI'y at Interfaces
interact with carrier proteins that determine selectivity. Finally, we Some researchers draw the analogy between atoms and nanoparti- D -
introduce a new high-throughput synthesis and screening method cles, yet as chemists, we are lUSt beginning to realize the nanoparti- t0 LlJ
to identify protein resistant surfaces. cle equivalents of molecules and extended materials. One of the E" 8 l
fundamental challenges facing nanotechnology researchers in this 0'; >0 m SPEAKERS
10:00 am. Break (refreshments available) area is the development of a method to programmably assemble E x (b 3
10:10 am. Dr. Ralph G. Nuzzo these nanoparticles into complex 1-, 2-, and 3-dimensional structures. CD 3 O 0
University oflllinois, Urbana-Champaign The ability to create these nanoscale architectures would provide a .C 'i-' "D
D . . . . . .. . . . . . c 0 Lu Georges Belfort
evrces, Fabrication Methods, and Functional means to increase sensrtrvrty, speed, and functlonallty ln electronic, 0 (D <- [r
Materials for Discovery in Biological and Bioanalytical therapeutic, and diagnostic devices relative to current benchmarks, 5 x >_ LlJ Ralph G. NUZZO
Chemistry as achieving such a feat would allow for the synthesis of designer .._, 5 X 0 Paul s Weiss
. _ . . ' . . materials, wherein the physical properties of a material could be 8 >   '
The fabrication 0f high performance lntegrated crrcurts provrdes predicted and controlled a priori. Our group has taken the initial steps E r: S E
examples of the most sophisticated materials fabrication methods, towards this goal and developed a means of creating tailorable as- t K) *5) J
as well as the most high performance materials, used in any area sembly environments using DNA-nanoparticle conjugates. These to Cl) C U) _ _
of modern technology. The advanced functional systems they nanobioconjugates combine the discrete plasmon resonances of gold 8% i (0 Friday, April 8, 2011
provrde are ones that are generally characterized by a massive nanoparticles with the synthetically controllable and highly selective D D 3 U)
integration of circuit elements within compact, rigid and essentially recognition properties of DNA, making them both usefu| nanoscale UJ
Planar device form factor devices. Such features, while well suited building blocks and benecial materials in their own right. This talk [I .
to the requirements 0f electronics, are less enabling for the Classes will focus on the history of these conjugates, as well as recent ad- D Department Of Chemistry
of devrces and modes Of Operation that enable the study and ma- vances and potential applications of both the conjugates and their  0 University of Kentucky
nlpulatlon 0t blologlcal systems. For the latter, the desrgn rules and assemblies in medical research, gene regulation, therapeutics, and < -
forms of materials integration involve numerous interesting but diagnostics. LeXithon, KY 40506-0055
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